This monograph comprises seven chapters, each detailing recent advancements in the field of cardiovascular research. Chapter One describes the various benefits that progesterone has on the cardiovascular system. Chapter Two aims to describe congenital heart disease in well-characterized syndromes and update the possible causes of genetic origin. Chapter Three aims to update and review the hemodynamic evaluation and percutaneous intervention in congenital heart disease. Chapter Four is focused on the evaluation and treatment of intermediate coronary plaque. Chapter Five presents a review of the literature on the field of disseminated intravascular coagulopathy and analyzes several factors regarding the management of such cases. Chapter Six aims to identify predictors of the vulnerability and assessment in dynamics of the morphology of coronary plaques in patients with stable coronary artery disease. Finally, Chapter Seven reports on the case of a patient with rheumatic heart disease who underwent double valve replacement and incidentally was diagnosed with emphysematous pyelonephritis during his post-operative course in the hospital.