The past three decades witnessed a plethora of scientific investigations into the pathogenesis of diabetic nephropathy, which attempt to seek the role of several potential cytokines, growth factors, second messengers, vasoactive factors, and candidate genes in leading to structural and functional demise of the kidneys in diabetes. Establishing more extensive knowledge of pathogenesis is crucial to expand the therapeutic options for diabetic nephropathy. While there are a few monographs dealing with the subject of diabetic nephropathy, this book is an exclusive treatise on the current knowledge about the pathogenesis of this condition. This book offers the most current data on the pathogenic factors incriminated in the nephropathy of diabetes.