Universities are a relevant instrument in the facilitation of the contemporary knowledge-based economy because they support the generation and the exploitation of knowledge through education, research and entrepreneurial activities. As a consequence, they generate added value, with their knowledge transformed into social and economic development. Also, changes attributed to social and economic developments have generated different impacts on universities. For these reasons, governments around the world are attempting to make universities more entrepreneurial, above all, in order to increase their capabilities to generate entrepreneurs and transmit their innovations to society. This book examines entrepreneurial universities in Spain as a clear example of government interest in improving the entrepreneurial spirit at all educational levels.