This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed include the effect of aroma massage on constipation in advanced cancer patients; the histamine role in cell migration and matrix remodelling; neuronal histamine circuits as modulators of cognitive processes in the brain; cationic cell penetrating peptides mediating hemodynamic changes through mast cell activation; lipid emulsions for intoxications with membrane stabilising agents; the pathomechanics and management of perilunate dislocations; and robotic arm-assisted orthopaedic knee arthroplasty.