Developments in computer technologies and telecommunications make e-learning a natural evolution and extension of traditional lecture driven style learning. E-learning technologies can extend course content with multimedia systems, active learning opportunities and instructional technology to facilitate education in all areas of study to a broad range of learners. E-learning allows for the creation of learning communities that overcome the constraints of time, distance, and boundaries. This book covers a wide range of interesting e-learning topics. The first four chapters cover the background, evolution, new technologies, and the 2nd generation of e-learning in the 21st century. Chapters 5 and 6 cover the advancement in e-learning tools. The rest of the book covers a wide range of modern applications of e-learning in several important areas such as: medical related applications (Chapters 7, 8, and 9), social networks (Chapters 10 and 11), culture impact on e-learning (Chapters 12, 13, and 14) and traffic related issues (Chapter 15).