This volume includes seven chapters that present some of the latest advancements in cancer research. Chapter One studies the correlation between smoking and cancer using the sequenced human genome. Chapter Two discusses glucose-regulated protein 78-mediated regulation of epithelial-mesenchymal transition, the apoptotic and autophagic signaling pathways, and how it can be used as a therapeutic against cancer. Chapter Three discusses new approaches in the treatment of hodgkin lymphoma. Chapter Four includes a review of the etiology, diagnosis and therapeutic management of rare pancreatic tumors. Chapter Five introduces recent progress on the mechanism of action and predictive biomarkers of mitomycin C using a genome-scale CRISPR/Cas9 knockout screening approach. Chapter Six discusses ultrasonography, endometrial sampling, magnetic resonance imaging, and computed tomography in the context of endometrial cancers. Finally, Chapter Seven discusses treatment options for papillary thyroid carcinoma.