Enterobacter is a relatively lesser known member of family Enterobacteriaceae with at least fifteen species more or less involved in different human infections. As little knowledge is available about its pathogenicity and virulence factors, this compilation discusses the factors and genes involved. The plants and microbes with antimicrobial potential in the synthesis of nanoparticles for the control of pathogenic Enterobacteriaceae are highlighted, and the authors discuss how, to overcome the complexities regarding antibiotic therapies and multiple drug resistance, there is a dire need to develop some novel clinical approaches and strategies. The factors causing multi-drug resistance are highlighted, including under or overuse of antibiotics, prolonged use of antibiotics, poor infection control, poor hygiene and sanitation.