In the first chapter of Horizons in World Cardiovascular Research. Volume 14, the secondary mechanical complications of acute coronary syndrome are discussed while presenting initial treatment methods by way of pharmacology. These complications typically occur swiftly (acute phase and subacute phase) and they originate in the severe cardiac expansion zones, in border regions with the healthy tissue as well as the infarcted tissue. The second chapter explains that preeclampsia, a pregnancy-specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation, is a major complication in pregnancy, occurring in 7-10% of all pregnant women, and is one of the major causes of maternal morbidity and mortality, preterm birth, intrauterine growth restriction (IUGR), and perinatal mortality. The author explores the way in which markers of endothelial dysfunction could be used to predict hypertensive disorders in pregnancy. The third chapter examines modern percutaneous technologies for the controlling of valvular heart disease, with the goal of pinpointing new opportunities for research. Additionally, the utility of various emerging balloon valvuloplasty techniques, MitraClip, and valve-in-valve approaches are explained in the hopes that understanding their limitations might aid in new research. Molecular domains in heart muscles in family members are classified in the fourth chapter, with the intention of ascertaining the effect of vasodilator agents, sugar, and hypoxia on the operation of protein domains. The domains inside the heart aorta and vein of a slaughtered domestic pig are studied to ascertain how acetylsalicylic acid (ASA), ramipril, sugar, heat and physical exertions influenced them. Next, research on the link between family history of depression and atherosclerotic coronary artery disease is presented in the fifth chapter. Depression is one of the leading contributors to the global burden of diseases, and is one of the major risk factors for cardiovascular disease, therefore it is essential to develop a link between how genetics and inheritance in families may worsen the prognosis of cardiovascular disease in offspring. The sixth chapter supports the claim that ivabradine should be the primary pharmacologic treatment for patients with symptoms of inappropriate sinus tachycardia by ruling out other possible causes.