Hidradenitis suppurativa, or acne inversa, is a chronic inflammatory skin disorder clinically characterized by acne-like skin lesions, follicular occlusion and recurrent inflammation. The underlying cause of the disease is not clear, but effective treatment relies on resection of all involved skin and subcutaneous tissue. As such, Hidradenitis Suppurativa: From Diagnosis to Treatment details specific operative nuances of affected locations and surgical approaches to localized, regional, and more systemic disease. The surgical management of moderate to severe hidradenitis suppurativa affecting the axilla is explored in the context of the excision and reconstructive techniques available. In closing, the authors discuss evidence-based therapeutic approaches for the management and treatment of hidradenitis suppurativa and how, most commonly, a multimodal treatment plan is required for optimal response.