Atherosclerosis and stroke are two leading causes of age-associated disability, dementia, and death. The Centers for Disease Control and Prevention (CDC) and the National Center for Health Statistics recently reported that Alzheimer's Disease has surpassed diabetes as a leading cause of death. Alzheimer is now the sixth-leading cause of death in the United States. This book discusses the roles of oxidative stress, mitochondria failure, and cellular hypoperfusion in the context of Alzheimer Disease.