This book adheres to strict scientific principles and is designed to explore the whole aspect of gallstone disease from the micro world of the genetic profiles, basic metabolisms of bile lipids in cholesterol gallstone patients, to the macro world of clinical triple defects of gallstone patients. It is especially suitable for medical professionals: internists, surgeons, residents, nurses and medical students, and for collection by libraries. This book deals with motor dysfunction in calculous gallbladders as well as reactive oxygen species in relation to gallstone formation. Aetiology and pathogenesis of pigment, calcium carbonate and intra-hepatic gallstones are also discussed.