Lyme neuroborreliosis is a disorder of immense magnitude and importance. This volume on Lyme neuroborreliosis, authored by David S Younger provides up-to-date insight into the history, epidemiology, experimental animal models, blood brain barrier, clinical, serological and treatment aspects of this disorder in children and adults. This scholarly work on Lyme neuroborreliosis should appeal to neurologists, infectious disease specialists, hospital and office-based physicians who care for patients as well as academic investigators in the field of Lyme disease and pharmaceutical development. It is hoped that with the coming of tick season that brings cases of Lyme disease to the forefront, that health care providers in endemic regions for Lyme disease will be ready to diagnose the most difficult patients and avert the most dreaded complications, notably those of the nervous system.