Propofol is an injectable agent that is commonly used for general anaesthesia. In addition to its central nervous system depressant action, propofol may exhibit temporary analgesia although this has been debated. Several studies have reported analgesic effects of subhypnotic doses of propofol on pain perception in humans. Moreover, some recent clinical studies have reported that surgery patients receiving propofol anaesthesia experienced reduced postoperative pain. This book discusses the pharmacokinetics, medical uses and potential health effects of propofol in further detail.