H∞ Robust design is an advancing technology which aims to achieve the system design purpose under intrinsic random fluctuation and external disturbance. This book introduces several robust design methods, some of which include linear to nonlinear systems and frequency to time domain. This book provides not only a complete theoretical development and application of H∞ robust design over the last three decades, but also an integrated platform for control, signal processing, communication, systems and synthetic biology. Based on the theoretical H∞ robust design results, the authors also give some practical design examples to illustrate the procedure and validate the performance of the proposed H∞ method with computational simulations and tables.