This book is a compilation of peer reviewed chapters which address the dynamics of biodiversity and ecosystem services (ESSs) used at Lake Ngami in Northern Botswana. This book focuses on the implications of the ESSs used in terms of human well-being and sustainability, with Lake Ngami as a case study. Three broad cross-cutting themes are addressed: 1) The interaction between ESSs and direct drivers of ecosystem change such as flooding, climate change and variability; 2) the relationship between ESSs and institutions (rules, beliefs, norms, markets and property rights); and 3) the relationship between changes in ESSs and human well-being. In order to address these themes, the authors have divided the book into five parts: 1) Introduction and Background, 2) Supporting and Regulating ESSs, 3) Provisioning ESSs, 4) Cultural ESSs, and 5) Strategy for ESSs’ Governance and Policy Implications. The book demonstrates how the ESSs of Lake Ngami have the potential to make a substantial contribution to human-well-being. However, due to the variability in the flooding of the Okavango River, which results in decadal and longer dry periods in the lake, the benefits derived from ESSs by the local population cannot be guaranteed for the future. The contributors to this book are researchers with a plurality of backgrounds in natural and social sciences with diverse views. The policy recommendations suggested by some of the authors could contribute to the sustainable use and management of ESSs of wetlands in semi-arid environments.