Ketamine: History, Uses and Health Effects first compares the pathology of the urinary system in ketamin- treated mice with those treated by Uncaria rhynchophylla plus e and Gouteng-treated mice. This compilation goes on to assess the current literature regarding the effectiveness and the adverse effects of ketamine in burn pain management, coming to conclusions about its potential clinical use for burns among children and adults. Following this, the authors provide cellular, and molecular evidence regarding the ketamine effects in clinical and preclinical models of major depressive disorder. A critical review on ketamine and other phencyclidine analogues, namely the most consumed metoxethamine, 3-methoxyphencyclidine and 4-methoxyphencyclidine, is also provided. Lastly, a new approach for the on-site detection and quantification of ketamine based on the isolation of its product of reaction with gold bromide onto nylon filters and subsequent digital color analysis is presented.