Since the Nobel Laureate Ilya Prigogine's dissipative structures and the outstanding work by Maturana and Varela, an exhaustive idea of what human mind is has lost its fascinating value and did not fund an epistemology anymore, falling down in the abrupt concept of a machinery or a mechanism. A failure, somehow, in interpreting what is life and the human being, arose from the dismiss of a sound epistemology or a basilar philosophic foundation of biology, which yet found an interesting contribution with Maturana's and Varela's scientific efforts. In this book, we attempted to build a new epistemological model of life and the human mind taking into account the intriguing model of Prigogine's dissipative structure. Our model addresses, for the first time, three modalities of dissipation, besides dissipation in the thermodynamic field, introducing a Shannon's dissipation and a relational dissipation, able to give suggestive insights why life arose, mind developed and humans engage relationships. A new hypothesis on the origin of mind is presented. The book is exposed as an encouraging occasion to deepen our biological fundamental rules, giving amazing suggestion on our personal and social behaviours. Finally, it suggests a new psychotherapeutic approach to address important concerns about relation and affective life.