A Closer Look at Kinase Inhibition opens with a discussion on the roles of various tyrosine kinases inhibitors and molecular mechanisms of acquired resistance to tyrosine kinase inhibitor drugs therapy in colon-rectal cancer. The authors summarize host cell and viral protein kinases, the progress in their use, and the repurposing of approved kinase inhibitors as broad-spectrum antivirals. The key kinases, namely CLK1, DYRK1A, CDK5, GSK3 and CK1, are analyzed as data indicate that targeting these proteins may have therapeutic promise against Alzheimer's disease.