Volume 21 first addresses the negative consequences of polypharmacy in older adults, highlighting evidence-based approaches to decrease inappropriate prescribing. An overview of generic drugs in Brazil is provided based on an analysis of literature on the subject, as well as public data. The authors assess the significant role phytochemicals play in combatting coronary heart disease, chronic inflammation, cancer, diabetes, Alzheimer disease, and more. Also assessed in this compilation are the different pathways of NF-κB signaling in cell survival and pathogenesis of a variety of diseases affecting humans. Hydrocephalus, a disorder characterised by an excessive accumulation of cerebrospinal fluid inside the ventricles of the brain, is explored in detail. In addition, a new experimental model of non-exudative age-related macular degeneration induced by superior cervical ganglionectomy in C57BL/6J mice is presented, focusing on differences in the histology, ultrastructure, and metabolic attributes of the temporal retinal pigment epithelium. The signs, symptoms, and radiological findings regarding isolated fallopian tube torsion are examined, as well the various surgical options available. The diagnosis of post-cerebral infarction seizures, or post-stroke seizures, is studied in closing, and electroencephalography is put forward as a crucial tool for this purpose.