This book opens with a description of the insulin-like growth factor system, with focus on the insulin-like growth factor receptors and functions associated with them. The data on membrane proteins, their N-glycome and oxidation status id related to the authors' findings on the receptors in different physiological and pathological conditions, such as normal and abnormal tissue growth and development. Next, a review of the current methods used to prepare and study membrane proteins is presented, with focus on large scale simulations and special emphasis on scalable parallel methods. In closing, commandments surrounding integral membrane protein expression and purification, integral membrane protein biochemistry, integral membrane protein functionality studies and integral membrane protein high-resolution structures are described.