By using mathematical models to describe the physical, biological or chemical phenomena, one of the most common results is either a differential equation or a system of differential equations, together with the correct boundary and initial conditions. The determination and interpretation of their solution are at the base of applied mathematics. Hence the analytical and numerical study of the differential equation is very much essential for all theoretical and experimental researchers, and this book helps to develop skills in this area. Recently non-linear differential equations were widely used to model many of the interesting and relevant phenomena found in many fields of science and technology on a mathematical basis. This problem is to inspire them in various fields such as economics, medical biology, plasma physics, particle physics, differential geometry, engineering, signal processing, electrochemistry and materials science. This book contains seven chapters and practical applications to the problems of the real world. The first chapter is specifically for those with limited mathematical background. Chapter one presents the introduction of non-linear reaction-diffusion systems, various boundary conditions and examples. Real-life application of non-linear reaction-diffusion in different fields with some important non-linear equations is also discussed. In Chapter 2, mathematical preliminaries and various advanced methods of solving non-linear differential equations such as Homotopy perturbation method, variational iteration method, exponential function method etc. are described with examples. Steady and non-steady state reaction-diffusion equations in the plane sheet (chapter 3), cylinder (chapter 4) and spherical (chapter 5) are analyzed. The analytical results published by various researchers in referred journals during 2007-2020 have been addressed in these chapters 4 to 6, and this leads to conclusions and recommendations on what approaches to use on non-linear reaction-diffusion equations. Convection-diffusion problems arise very often in applied sciences and engineering. Non-linear convection-diffusion equations and corresponding analytical solutions in various fields of chemical sciences are discussed in chapter6. Numerical methods are used to provide approximate results for the non-linear problems, and their importance is felt when it is impossible or difficult to solve a given problem analytically. Chapter 7 identifies some of the numerical methods for finding solutions to non-linear differential equations.