In this compilation, the authors provide an overview of neural plate pre-patterning and the concept of the organizing center, describing the contributions of informative cues and signaling pathways involved in zli positioning. Continuing, The Forebrain: Development, Physiology and Functions aims to show the existence of specific neuronal populations in basal forebrain linking with specific sensory, motor and prefrontal cortices. In addition, the electrophysiological properties of cholinergic pathways that control cortical activity are examined. In closing, the authors discuss the putative involvement of Reelin signal in motor-related impairments observed in neurological diseases, including lissencephaly, psychiatric disorders and brain injuries.