Despite a wealth of epidemiological evidence of the profound ill-effects of smoking on human health, we know surprisingly little about the pathogenic mechanisms by which tobacco smoke actually causes disease. Indeed, to our knowledge this publication represents the first book that is entirely devoted to the molecular and cellular mechanisms of tobacco-induced diseases. Considering that smoking will directly kill 650 million of those people currently alive, the lack of such a book represents a huge gap in the biomedical literature. This important book fills this gap.