Lesions affecting the oral cavity are unique and different from those affecting the other parts of our body. Clinical, radiological, histopathological and cytological diagnosis may be insufficient. Confirmation by immunohistochemistry, immunocytochemistry tissue arrays, etc needs to be done. In a bid to identify the various lesions, some authors have experimented with a large number of markers in their laboratories all throughout the world. But for a busy dental practitioner or a postgraduate student, it is a painstaking proposition to scan through each of the relevant articles. This handbook is a compilation of all the immunohistochemical markers that those authors have experimented on and are commonly used by postgraduate students as well as by dental and medical doctors of all specialties in the immunohistochemical laboratories to identify the divisive dental lesions. The information provided herein will help in immunohistochemical staining and enable to know the biomarkers to be used for the most common yet controversial lesions pertaining to the oral cavity. It will also facilitate a proper diagnosis of the specimens from the departments of Oral and Maxillofacial Pathology, Oral and Maxillofacial Surgery, Oral Medicine, Diagnosis and Radiology and Periodontology.