Although initially thought to be a deleterious influence on tissue repair and remodelling, recent studies have shown the versatility of the mast cell in modulating tissue responses in a beneficial as well as an adverse manner. Hence it is clear that understanding mast cell biology in the context of normal and abnormal tissue repair and remodelling will be crucial to preventing and treating cardiovascular disease. This book brings together world-renowned scientists in the field of mast cell biology to present the current knowledge regarding the role of these enigmatic cells in cardiovascular disease, and innovative research approaches to tackle this field of cardiovascular investigation.