This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed include innovative drug delivery systems for the prophylaxis of HIV/AIDs and prevention of STIs; adiponectin production and role in disease; adverse drug events associated with anticonvulsants; neonatal resuscitation practices; total knee replacement using the kinematic navigation system; chest compressions during CPR and the clinical use of concentrated autologous bone marrow aspirate transplantation for osteonecrosis of the femoral head and bone non-union.