This book discusses the global attitudes regarding blood donations, its safety and future directions. Chapter One provides a brief overview of the ethics of blood donations. Chapter Two focuses on the epidemiological aspects of the hepatitis C virus infection among seekers of serological tests in blood banks in Pará, Brazilian Amazon. Chapter Three discusses statistical control of the production of blood components using variables and attributes charts, and capacity indexes. Chapter Four demonstrates the use of cluster analysis and item response theory for the assessment of transfusion-related knowledge of nurses. Chapter Five reviews a quantitative/qualitative approach to better understand motivations of apheresis donors in Quebec, Canada.