This volume includes five chapters dealing with some of the latest advances in medicine and biology. Chapter One pontificates on the impact of the sequencing of the human genome on the search for life in the universe. Chapter Two summarizes current understanding of how to assess endothelial dysfunction, main risk factors, mechanisms underlying its development, prognostic implications, and biomarkers. Chapter Three assesses the effects of the hormone irisin on glucose metabolism. Chapter Four highlights the common disorders that need to be considered as a differential diagnosis for neuromyelitis optica spectrum disorder and features that help in their differentiation. Finally, Chapter Five deals with tapered modular femoral components in revision total hip arthroplasty.