Biofilms have grown into a major issue that poses hazards to all life forms. This book reviews strategies which can be employed to combat biofilms. Chapter 1 demonstrates that microbial biofilms are generated when a polymeric matrix surrounds a collection of single or heterogeneous microbial organisms. Chapter 2 discusses how biofilm resistance to antimicrobial drugs has become a global problem for medical researchers. Chapter 3 discusses how even though antibiofilm tactics are helpful, they are still worth investigating because each strategy is limited by physiological parameters such as composition, osmolarity, and bacterial species. Chapter 4 reveals that biofilms are diverse microbial societies dwelling in diverse environments. Chapter 5 confers emerging biofilm eradication tendencies and tactics, as well as the treatment of biofilm-related medical problems. Chapter 6 examines how biofilm's pervasiveness makes its removal extremely challenging. Chapter 7 looks at a variety of recently discovered nano-established biomaterials as well as the approaches that are being used to create antibiofilm surfaces. Finally, Chapter 8 discusses how microbial biofilms, which are generated by the aggregation of single or varied microbial species encased in a polymeric matrix, are a frequent way for bacteria to shield themselves against environmental challenges and antibacterial treatments.