This book provides an overview of the advances in the synthesis of PCL, PCL-based biomaterials, and designing of appropriate PCL structures keeping in view of their applications in biomedical (orthopaedic implant), tissue engineering including bone, cartilage, skin, and cornea, protecting agent for material for medical devices and food packaging. The book shall be of special interest to material scientists, tissue engineers, medical scientists, mechanical engineers and biotechnologists with a better understanding of the physico-chemical and biological characteristics of PCL biomaterial to develop more appropriate and innovative, PCL-based composite materials for a wide field of applications. I hope the researchers, scientists, medical/healthcare professionals and industries shall find all these contributions interesting and will be inspired from reading to broaden their research towards the PCL-based material development and manufacturing of innovative products and devices from these materials.