In early modern times, Seville was the most important hub for the transatlantic economy. It attracted a large number of foreign merchants who connected the American with the European markets. While the transatlantic axis of this trade has drawn much attention in historiography, the connection between Seville and the European Atlantic coast has largely been ignored. Therefore, this book analyzes the central actors of this trade route who were the Flemish and French merchants of Seville. Following their commercial activities, it shows features of their private and business networks in Seville and displays fundamental structures and processes of the European and transatlantic economy.