What do we know about reality? What can we know at all? This is the question that the essays on religion (especially Buddhism and Christianity) and natural science in this volume address. Instead of getting lost in theoretical constructs and dogmatic discussions, the contributors focus on the philosophical issues that span the world. How do Buddhism, Christianity and science deal with the boundaries between what man can know and what he cannot know? How is that defined that cannot be known? How does ignorance relate to the human striving to fully grasp its surrounding reality? Scientists and religious figures discuss these questions and try to integrate the other side of the understanding of reality into their approach. This creates a fertile ground for the dialogue between science and religion, which makes it possible to think together about the limits of understanding.