Name: New Developments in Calcium Signaling Research
Brand: Nova Science Publishers, Inc (US)
SKU: 9781629486017
Price: 80.59 GBP
Availability: InStock

New Developments in Calcium Signaling Research

Edited by: Masayoshi Yamaguchi

Published by Nova Science Publishers, Inc (US)

In Stock

£123.99

£80.59

Published: 01-Mar-2014
ISBN: 9781629486017

Paperback
141 Pages

Subjects:
Medical research

Quantity

The calcium metabolism in the living body is skilfully regulated through calcium-regulating hormones, including the parathyroid hormone, active vitamin D3 metabolite and calcitonin. The blood calcium concentration is ten thousand-fold compared with the levels in cells. Cells use extracellular calcium to regulate cell function efficiently. Intracellular calcium homeostasis is exactly regulated through the mechanism related to various calcium transport systems in cells. Signal transduction plays a pivotal role in cellular regulation. Calcium signalling is probably the most ubiquitous cellular signal that mediates the action of many hormones, cytokines, and neurotransmitters. Calcium regulates the activity of numerous calcium-dependent proteins including protein kinases, protein phosphatases, protease and other calcium-regulating factors involved in calcium signalling. Calcium signalling plays a pivotal role in the regulation of manifold cellular functions including cell proliferation, apoptosis and gene expression. This book focuses on recent topics in calcium signalling and its related diseases.

Masayoshi Yamaguchi, Ph.D., IOM, FAOE, DDG, DG, is Adjunct Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA (2013 - ). Dr. Yamaguchi is engaged in the fields of endocrinology and cell signaling since 1971, and these researches are developed in the aspect of biochemistry, molecular biology, endocrinology, metabolism, nutrition, pharmacology, and toxicology. Dr Yamaguchi has an interesting for cell signaling mechanism, bone biology, nutritional factor and osteoporosis prevention, diabetes and diabetic osteoporosis, cancer biology, and cancer cell bone metastasis. Dr. Yamaguchi discovered two novel proteins and genes; cell signaling suppressor protein (named regucalcin; 1978) and transcriptional factor RGPR-p117 (regucalcin gene promoter region-related protein; 2001). Dr Yamaguchi generated regucalcin transgenic rats, which were registered as international patents including USA, EU and Japan, and this animal was found to induce osteoporosis and hyperlipidemia. Moreover, Dr. Yamaguchi proposed the potential role of regucalcin as a key suppressor protein in carcinogenesis. Thus far, Dr Yamaguchi published over 550 English articles to professional journals with peer-review, and registered over 20 national and international patents.