In addition to the role of educating future citizens, schools today respond to other social needs, especially to help promote health. The school, in fact, is a unique place to intercept the ways of thinking of children, adolescents and young adults. Very often, however, the school attaches great social responsibility without adequate support to achieve it. From this comes the need to provide educational resources to the roles and responsibilities in order to address the issues that the company asks them to deal with and that the issues of health and education are anointed synergistically. The present work aims to create a link between the promotion of health and school, describing in the first part, the international reference standards, the various theoretical approaches that exist today, and the evolution of the various models of intervention: from the bio-medical to the bio-psycho-social to interactive-dialogical. The second part, after having carried out a historical analysis of some of the themes in the last decade which have resulted in a particularly difficult management of the school (smoking, bullying, delinquency, intercultural) presents some methodological guidelines designed to intervene at the operational level, for the benefit of school leaders, teachers, health workers, parents, psychologists and educators.