In this volume, the assumption that origins can be defined as a hermeneutic paradigm in the humanities and in the sciences is explored in relation to specific theoretical frameworks and research methodologies. By investigating how origins have been conceptualised in different domains of knowledge – biology, primatology, psychology, linguistics, history of science, critical theory, classical studies, philology, literary criticism, strategy and accounting – a double movement has been generated: towards the very core of each discipline and beyond disciplinary boundaries. Which are the most productive theories and methods each discipline has elaborated for investigating origins? Can they become trans-disciplinary? Which synergic enquiries can be devised in order to expand and share knowledge? Explaining how and why various disciplines have responded to such questions involves delving into their histories and cultural ideologies in order to verify whether the topic of origins can function as a powerful connector between scientific and humanistic territories.